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RTD ALPHA-BISABOLOL NATURAL

INCI Name: Bisabolol
Product Code: 0140
CAS #: 515-69-5 or 23089-26-1
EINECS: 208-205-9 or 245-423-3
Brand: RTD™ Specialties

Natural alpha-Bisabolol, also known as Levomenol, may be obtained from the direct distillation of the oil from the tropical shrub candeia. This shrub, Linnean name Vanillosmopsis erythropappa, which is of the Asteraceae family, grows in the southeast and midwest regions of Brazil. This tree yields a white, hard, resinous wood and its leaves, flowers and oil have medicinal properties.

Natural alpha-Bisabolol is also a major constituent of German Chamomile [Chamomilla Recutita (Matricaria) Flower Oil], which has been used in the traditional medicines of Europe for hundreds of years. The essential oil of chamomile contains up to 50% 1-alpha-bisabolol.

RTD Alpha-Bisabolol Natural is an optically active viscous colorless to somewhat yellow liquid with slight characteristic floral wood odor. It contains at least 95% (-)-1-alpha-bisabolol, a monocyclic unsaturated sesquiterpene alcohol. Alpha-Bisabolol, which is nontoxic and nonirritating to the skin, has been shown to possess anti-inflammatory and wound healing properties, as well as antimycotic and antibacterial effects. Specifically, it is a potent inhibitor of fungi, Candida albicans and gram-positive bacteria.

RTD Alpha-Bisabolol Natural is suitable for use in skin care products where the formulator wishes to take advantage of its anti-inflammatory, bactericidal and antimycotic properties, which make it a preferred active ingredient for protection of skin against stresses including cleansing, shaving, depilation, and sun exposure. When RTD Alpha-Bisabolol Natural is used at low levels (0.1 – 1.0% is recommended), it is active, safe, and skin compatible.

NATURAL VS. SYNTHETIC BISABOLOL

As previously noted, the essential oils of both chamomile and candeia are good botanical sources for preparing 95+% pure (-) alpha-Bisabolol. Bisabolol can also be made by chemical synthesis. The substance thus obtained, however, is only about 85% pure Bisabolol and, further, is a racemic mixture of both levorotary and dextrorotary isomers. So the synthetic product contains only about 42% of active (-) isomer. When considering the cost effectiveness of natural vs. synthetic material, remember that 1 kg natural Alpha-Bisabolol contains a minimum of 950 g active (-) Alpha-Bisabolol, while 1 kg synthetic Alpha-Bisabolol contains only about 425 g active (-) Alpha-Bisabolol. So on an “actives” basis, RTD Alpha-Bisabolol Natural is about 2.24 times more potent than synthetic material.

RTD Alpha-Bisabolol Natural is well-absorbed following dermal exposure, and formulators should be aware of the potential for Bisabolol to increase the penetration of other components of cosmetic formulations.

Features & Benefits:

  • Anti-inflammatory Agent
  • Bactericidal Agent
  • Fungicidal Agent
  • Healing Promotion
Appearance Viscous liquid, colorless to yellowish
Odor Slight characteristic floral wood odor
Density (g/cc) 0.93 (20°C)
Refractive Index (20°C) 1.495
Flash Point (°C) 112 (Pensky-Martens closed cup)
Optical Rotation (degrees) -57
Boiling Point (°C) 265
Insoluble In
  • Glycerin
  • Water
Soluble In
  • Alcohol [Ethanol]
  • Fatty Alcohols (molten)
  • Glyceryl Esters
  • Isopropyl Alcohol
  • Paraffin
Toxicology Profile
  • CIR Expert Panel: Safe as used (at up to 1%) in cosmetic formulations as diverse as lipsticks and underarm deodorants.
Packaging
  • Bottle - 5kgs

Regional Approvals:

  • US

Applications:

  • After Sun Skin Care
  • Bath Additives
  • Beach Wear Sun Care
  • Cleansing Wipes
  • Daily Wear Sun Care
  • Deodorants
  • Depilatories
  • Eye Area Color Cosmetics
  • Facial Cleansers
  • Facial Color Cosmetics
  • Facial Skin Care
  • Foot Care
  • Hair Conditioners
  • Hand & Body Care
  • Lip Care
  • Nail Care
  • Shampoos
  • Shaving Products
  • Shower Gels/Body Washes
  • Styling Aids

Formulas:

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Name Regional Acceptance  Formula Number
Advanced Lift LotionGlobalCS17-033-02C
Antiperspirant Roll- OnUS, EURD06-43-13
Baby Skin BarrierGlobalCS17-107-09E
Heal and Repair CreamASEAN, Australia, EU, Japan, MERCOSUR, USCS16-010-03B
Olive Mattifying MousseGlobal051-15-05F

The information presented herein is believed to be accurate and reliable, but no warranty or guarantee, expressed or implied, is made regarding the information or the performance of any product. Further, nothing contained herein shall be taken as any inducement or recommendation to use, manufacture or sell that may infringe any patents or any other proprietary rights now or hereafter in existence, nor to imply compliance with any regulatory requirements

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